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For topical cosmetic use, GHK-Cu ingredients have been in commercial skincare formulations since the 1990s with a broad consumer safety record and no pattern of reported systemic harm in healthy individuals

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Long-acting, subcutaneously administered, PYY RA are undergoing early phase clinical trials as obesity treatments either alone or in combination with GLP-1 RA (Table 1, NCT02568306 and NCT03574584)