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The inclusion and exclusion criteria were defined in direct accordance with the PICOS framework
Epigenetic clocks are well validated as research tools and have consistently been shown to predict how many healthy years people are likely to live, as well as their risk of chronic disease, disability and death
Figure 1 A reduction in estradiol levels, as found in the menopause, would therefore be expected to result in increased food intake (with the estradiol activity lost)
Effects build gradually over weeks to months if prescribed
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