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The field has evolved from the 2-minute half-life of native GLP-1 to engineered analogs that persist for a week a 5,000-fold improvement achieved through fatty acid conjugation, D-amino acid substitution, cyclization, and depot formulations

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Exenatide and metformin express their anti-inflammatory effects on human monocytes/macrophages by the attenuation of MAPKs and NFkappaB signaling