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Thioredoxin reductases In mammals, three selenocysteine-containing thioredoxin reductase (TXNRD) isoenzymes have been identified in the thioredoxin system: cytosolic TXNRD1, mitochondrial TXNRD3, and testes-specific thioredoxin glutathione reductase (TXNRD3, also known as TGR)

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Wang L, Valencak TG, Shan T

It is highly expressed in the epithelium of the esophagus, duodenum of the small intestine, and cecum of the large intestine, suggesting its involvement in zinc efflux and absorption into the systemic circulation