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These included patients who started their treatment with both drug classes on the same day at the start of follow-up and those who added on a GLP-1 receptor agonist or an SGLT-2 inhibitor for the first time at some point during the follow-up (up until 29 March 2021)

10.1016/j.appet.2013.09.025 Appetite 91 Garcia-CabrerizoR.CarbiaC.KjO

Surface charge and hydrophilicity primarily influence plasma protein adsorption, clearance by the mononuclear phagocyte system and overall circulation time [33, 37, 39]

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Glutathione is an antioxidant produced naturally by the liver, and a decrease in levels causes serious problems