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Figure 3 Table 3 Gut dysbiosis affect hypothalamus (gut-liver-hypothalamus axis)

First characterised by Raun and colleagues at Novo Nordisk in 1998 (PMID: 9241518), Ipamorelin was designed to deliver potent GH stimulation with a selectivity profile that makes it tractable for isolated study of GH-axis effects without confounding stress-hormone activation