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When patients increase from one dose to the next higher level (e.g., from 2.5 mg to 5 mg), they may experience a recurrence of gastrointestinal symptoms, though these are often less severe than during initial treatment and may resolve more quickly

Shaha C, Suri A, Talwar GP (1990) Induction of infertility in female rats after active immunization with 24 kD antigens from rat testes

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