Holst JJ, Orskov C, Nielsen OV, Schwartz TW
further confirmed that GLP-1 exerts a positive chronotropic effect by directly activating GLP-1 receptors expressed in sinoatrial node pacemaker cells
presented a magnetically targeted nanocarrier loaded with the PPAR agonist 15d-PGJ2-MNPs, which, when administered intravenously, activated PPAR receptors on macrophages around haematomas, attenuated brain damage, and improved sensory and motor functions in mice after ICH (Wang et al., 2023)
No adjustments for multiple comparisons were made given the exploratory nature of the study
However, given its higher efficacy, tirzepatide may lead to more substantial long-term weight maintenance outcomes