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Co-enzyme B12 also interacts with the enzyme methionine synthase (5-methyltetrahydrofolate-homocysteine methyltransferase), required for the conversion of homocysteine to methionine, which is essential for folic acid metabolism and the formation of thymine, which is a component of DNA
The reason: since the fragment contains only the C-terminal part, it lacks the binding domains for GHR (most of the affinity of hGH for GHR lies in the central part of the molecule)
Olson CR, Fernndez-Vargas M, Portfors CV, Mello CV
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