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Key molecular modifications aimed at increasing hydrophobicity and decreasing hydrogen-bonding potential
Speichinger notes that sometimes there is a second step to the progesterone challenge, where estrogen is given first and followed by progesterone, to cause the withdrawal period
These include chronic kidney disease, tuberculosis, chronic heart failure and malnutrition
Reduced desensitization risk: Alternating receptor pathways mitigates receptor fatigue or downregulation seen in monotherapy 1-5
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