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Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2
The baseline GLP-1 sensitivity was 3- to 4-fold higher than that of GIP
They also promote macrophage polarization from the proinflammatory M1 phenotype to the anti-inflammatory M2 phenotype (Figure 2)
In addition to regulating apoptosis, GLP-1RAs also fine-tune mitochondrial quality control via mitophagy
Some evidence also points to potential anti-aging and muscle-preserving effects when paired with exercise and proper nutrition
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