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Lipid rafts (or cholesterol-rich nanodomains) are regions within the plasma membrane where weak binding between cholesterol and other phospholipids allows specific protein interactions to occur (Kiriakidi et al., 2019)
Phase 2 clinical trials involved 338 adults with obesity (BMI 30 or more) and overweight (BMI of 2729.99) with one or more weight-related conditions such as high blood pressure, high cholesterol levels, heart disease, and type 2 diabetes
Cell , 173(1), pp
20222023: Tirzepatide and the SURMOUNT Trials Tirzepatide (Mounjaro) raised the bar
Recombinant vs Chemical : Chemical synthesis is far more common: most (31 / 38) of the recently approved small peptide drugs are chemically synthesized
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