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The compounds effects are often highly concentration-dependent, and results obtained in one experimental context may not directly translate to others
(iv) the prevention and/or treatment of cardiovascular disease, such as the delaying or reduction of the development of a major adverse cardiovascular event (MACE) selected from the group consisting of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, revascularisation, hospitalisation for unstable angina pectoris, and hospitalisation for heart failure
The Cochrane reviewers call for more studies, but they also point out that there won't be any more folic acid studies in SCD [125]