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This delivery format also supports longer research projects where consistency between trials remains essential
The NHS gives its standard hydroxocobalamin treatment as an intramuscular injection, usually delivered by a nurse or doctor
A 2025 meta-analysis of 16 studies involving 6,098 participants found no statistically significant difference between intramuscular, oral, and sublingual B12 supplementation routes
The rate of change during this phase depends heavily on baseline body composition, caloric intake, activity level, and adherence to protocol
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