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For example, urolithin A can increase the expression of tryptophan hydroxylase-2 (TPH2) in differentiated rat serotonergic raphe cells via an increase in the transcriptional activity of 1,25-dihydroxyvitamin D 3 ( TPH2 expression was accompanied by a 3- to 4-fold increase in serotonin concentration in culture medium (Figure 1 summarizes the proposed theoretical framework for the effect of urolithin A on pathways relevant to sleep health
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