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Fluo-4 fluorescence intensity (excitation 480 nm, emission 520 nm) was measured as an indicator of calcium release in a multimode reader (Spark 20 M, TECAN)

The set of genes central to hepatic ethanol metabolism (alcohol dehydrogenase, aldehyde dehydrogenase and cytochrome P450) clustered almost entirely in sets X and Y (Supplementary Fig

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