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Consider increased clinical or laboratory monitoring for medications that have a narrow therapeutic index or that require clinical monitoring Use in Specific Populations Pregnancy: Available data with semaglutide use in pregnant women are not sufficient to determine a drug associated risk for major birth defects, miscarriage, or other adverse maternal or fetal outcomes

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Specifically, the use of genetic editing in human cells raises complex ethical considerations, particularly regarding off-target effects, potential germline modifications, and the long-term safety of edited cells in therapeutic contexts