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Many patients find the experience relaxing and use the time for meditation or quiet reflection

~60% reduction from baseline in a post-hoc analysis CORALreef HeFH (303 patients): 59% placebo-adjusted LDL-C reduction at week 24 Meaningful reductions also seen in non-HDL-C (5254%) and ApoB (4850%) Safety profile broadly similar to placebo

A useful way to hold this in mind is that each individual link (penetration, binding, expression change) has at least some support, but the field has not yet connected all the links into a single, independently verified causal chain running from an administered dose to a measured clinical benefit

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Semaglutide has an extensive base of large-scale RCTs