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Among those using it for weight loss, 20 out of 979 developed NAION, compared to three in the control group
Interestingly, inhibiting HDACs increases RB1 expression in MDSCs, halting their progression into immunosuppressive subsets and promoting their differentiation into cell types that enhance immune activity [106]
Reviewed February 2026
GLP-1R agonists were initially used to treat T2DM and soon after it was found that these drugs possess many other physiological properties, such as neuroprotection, neurotrophic, and anti-inflammatory effects, which may be useful to slow the progression of AD ( Figure 3 ) (17)
Common side effects - including nausea and gastrointestinal discomfort - are most prominent in early weeks and often reduce over time
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