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IGF-1 LR3 (Insulin-like Growth Factor 1 Long Arg3) is a synthetic variant of human IGF-1 , modified to increase both its potency and half-life

A meta-analysis sits at the top of the evidence hierarchy because it combines data from multiple independent studies

Asn205 was suggested to be crucial for tyrosinase activity through the activation of a conserved water molecule 35,46

IGF-1 in the CNS IGF-1 can cross the blood brain barrier (BBB) and enter CSF, and perform a number of important functions of the CNS, including neurogenesis and neuroprotection, through autocrine/paracrine or endocrine effects