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4.6 Overcoming translational barriers: In Vivo stability and manufacturing hurdles Despite the immense preclinical promise of nanomedicine in osteosarcoma, several significant translational barriers must be addressed before clinical implementation (59, 68)

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Apart from DSePA, our group has also studied the radioprotective activity of another organoselenium compound, dihydroxy-1-selenolane (DHS), which was earlier reported for GPx-like activity under in vitro conditions by Iwaoka and co-workers [93, 94]