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The oral glutathione supplement was slightly beneficial for skin lightening in particular subgroups, but the results were not statistically significant

The decreased production of estrogen in patients receiving GLP-1RA inhibits the collagen synthesis and increases the activity of metalloproteinase-1, leading to matrix collagen and elastin degradation

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Liraglutide follows a similar proteolytic cleavage pathway in various tissues, akin to the metabolism of other large proteins