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Native GLP-1 has been infused by the subcutaneous route (4.8 pmol/kg/min) using a portable insulin pump in a non-randomized study of subjects with type 2 diabetes over the age of 40 (mean age 55) with mean initial HbA1c of about 9%, and mean fasting glucose ~14 mM
Why Individual Response Times Differ So Much Genetic variation in GLP-1 receptor abundance and sensitivity explains why your coworker might lose 20 pounds in 6 weeks while you lose 10 pounds in the same timeframeboth scenarios reflect appropriate medication response for each unique body
For those exploring alternatives while waiting for survodutide, our guides cover switching between GLP-1 medications , managing tirzepatide plateaus , and peptide stacking strategies for weight loss
In related studies, Michael Nauck observed in 1986 that the incretin effect was lost or severely reduced in people with type 2 diabetes [10], making it unlikely that incretins would be useful therapeutically
Combined Protocol Considerations Running both compounds simultaneously does not appear to increase side effect severity for either
