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GHK-Cu's reported anti-inflammatory properties are based on preclinical findings and their clinical relevance in humans is uncertain
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Instead, the mechanism appears to involve GH receptor sensitisation at the tissue level: GHR (growth hormone receptor) mRNA expression in tendon tissue is elevated +2834% in BPC-157 groups vs vehicle (qRT-PCR, day 7 tendon healing model), and the downstream JAK2-STAT5 phosphorylation cascade is amplified without requiring elevated serum GH
Table 1), 34 patients (64.2%) had recurrent depression, 15 (28.3%) had bipolar disorder and 4 patients (7.5%) had a single depressive episode (DE)
