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These elements could be contributing to the high mortality rates and disabilities seen in those with diabetes (33)

Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion

Khajavi N, Beck A, Riku K et al (2023) TRPM7 kinase is required for insulin production and compensatory islet responses during obesity

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