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semaglutide in direct comparison The clearest head-to-head trial between the two approved molecules for obesity is SURMOUNT-5 (Aronne et al., NEJM 2024, NEJMoa2416394)
(3) Concomitant use of GLP-1R agonist or dipeptidyl peptidase-4 inhibitors
Recent studies suggest that bariatric surgery, even though it has higher upfront costs, may be a better deal in the long run
There are also medication alternatives for nausea management
Alzheimers and Dementia: Research is ongoing, such as the EVOKE/EVOKE+ trials, to determine if GLP-1 therapy can help mitigate early Alzheimers disease
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