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Patients with cancer cachexia also had significant deficiencies of L-carnitine in their skeletal muscles

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Tirzepatide differs from GLP-1RAs in that, in addition to agonizing the GLP-1R, this drug also acts as a GIPR agonist, providing direct effects on white adipose tissue that may further benefit MASH histology beyond glycemic control and weight loss [52]

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This resulted in differing numbers of patients influencing either end of the KaplanMeier survival curves and the possibility that the behavior of the patients at the beginning of the analysis may have differed from that of the patients nearer the end of the analysis

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