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FiorelliSPorroBCosentinoNDi MinnoAManegaCMFabbiocchiFet alActivation of Nrf2/HO-1 pathway and human atherosclerotic plaque vulnerability: an in vitro and in vivo study

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Subsequent work by Heffernan and coworkers (2001) confirmed the peptides effects in obese mouse models, with chronic administration associated with reduced body weight gain and decreased adiposity without concurrent changes in food intake

For a person with a confirmed deficiency, the documented dangers of leaving it untreated generally outweigh the rare, minor risks of the injections themselves