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Pernicious Anemia : This is an autoimmune disorder in which the body's immune system attacks and destroys the cells that produce intrinsic factors, leading to vitamin B12 deficiency

The proportion of participants achieving 20% or greater weight loss was 36% at the 10mg dose and 40% at the 15mg dose, results approaching what was previously achievable only with bariatric surgery

If it doesnt make it to the mitochondrial matrix, the fat will not get burned, even if you are following a strict diet or exercise regularly

See Homocysteine and Mild B12 Deficiency in Vegans for more info