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Most people adapt within months, but a meaningful minority, somewhere around 10 to 25%, have lasting changes: looser stools, urgency after fatty meals, or mild fat intolerance

Monitoring should include assessment of gastrointestinal tolerance, hydration status, renal function, limb measurements, pain levels, mobility, and quality of life indicators

Circulation 132 , e121e122 (2015)

At a poster spotlight session at the 2025 San Antonio Breast Cancer Symposium , researchers presented their recent findings on the effects of GLP-1s on people with breast cancer

In the landmark STEP trials, semaglutide produced average weight loss of approximately 15% of body weight over 68 weeks