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Crystal nephropathies: mechanisms of crystal-induced kidney injury

c-Src promotes tumorigenesis and tumor progression by activating PFKFB3

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The concept of hydrophobic tagging (HyT) is similar to that of PROTAC, but instead of using a ligand to recruit a specific E3 ligase, a synthetic hydrophobic group, such as adamantane, linked to a chemical moiety that specifically recognizes the protein of interest, assumes the role of recruiter for the degradation machinery 119 (Figure 6)