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Differential gene expression analysis was performed in R using DESeq2, version 1.18.1, with betaPrior set to TRUE to perform fold change shrinkage, and the significance threshold calculated at a BenjaminiHochberg adjusted p -value 1 FPKM, unadjusted p -value 1 FPKM, unadjusted p -value 1 FPKM, padj 2, ratio paired 2-tailed t -test) are not overall down-regulated or upregulated by anesthesia

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