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Those with a long half-life (weekly exenatide, efpeglenatide, liraglutide, semaglutide, albiglutide and dulaglutide) produce a sustained activation of rGLP1, resulting in a greater reduction in HbA1c, basal glycemia and body weight and would have fewer gastrointestinal side effects
Weinblatt ME, Keystone EC, Furst DE, Moreland LW, Weisman MH, Birbara CA, et al
The highest frequency of symptomatic complicated cholelithiasis was among liraglutide and semaglutide users rather than dulaglutide users
Tirzepatide combines the incretin effects of GLP-1 with GIP, the latter of which contributes to appetite regulation and further reductions in food intake
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