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184 However, other loci with more modest effects have not consistently replicated in subsequent studies examining their correlation with serum urate levels
The estimated mean reduction in HbA1c was -2.01 percentage points, -2.24 percentage points, and -2.30 percentage points with tirzepatide doses of 5 mg, 10 mg, and 15 mg, respectively, compared to -1.86 percentage points with semaglutide
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Magnetic resonance imaging (MRI) of mice During the early monitoring period, mice were anesthetized with 2% isoflurane through a nose cone and the survival of fat grafts was evaluated using a 9.4-T small animal MRI scanner (BioSpec 94/30, Bruker, Billerica, MA, USA), while continuously monitoring the body temperature and respiratory rate of the mice
demonstrated, in addition to higher weight loss in the group treated with high-dose liraglutide 3.0 mg/day for 32 weeks, significant improvements not only of fasting glucose and HOMA-IR, but also of the post-load glucose measured by OGTT, OGTT-derived insulin sensitivity index (SIOGTT), and corrected the early insulin response to a glucose challenge (IGI/HOMA) compared to placebo [62]
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