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Progressive overload becomes more nuanced: instead of simply adding weight, you manipulate volume, intensity, tempo, and rest periods to continue driving adaptation

According to a May 2025 WHO report, 2.5 billion adults worldwide were overweight in 2022, including 890 million having obesity

In more recent years, its also been approved for medical weight loss purposes, as higher doses have been shown to reduce hunger and encourage weight reduction

Pharmacol Ther (2022) 239:108277

Theres probably 50 years of research, and theyve been available for 20 years longer than most people realize, says Rekha Kumar, MD, an endocrinologist and obesity medicine expert at Weill Cornell Medical College and NewYork-Presbyterian Hospital in New York City