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The high reactivity of aldehyde and catechol moieties of DOPAL results in protein cross-linking and aggregation, aggravated proteostatic stress and neurodegeneration [9, 66]
PMID 2781235
A previous study by Zhao et al (25) reported that artemisinin prevents ferroptosis-induced liver injury by inhibiting reactive oxygen species (ROS) and inflammation through the activation of the nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1/glutathione peroxidase 4 (GPX4) pathway and downregulation of NF-B
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