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The 5-day window exists because semaglutide blood levels decline slowly
Weyer C, Gottlieb A, Kim DD, et al
Symptoms consistent with injection site-related muscle pain include pain that begins within 24 to 72 hours of injection, pain that is worse on the side of the body where injection occurred, and pain that improves or resolves when injection sites are rotated to different anatomical regions
Determination of total and oxidized glutathione in human whole blood with a sequential injection analysis system
The researchers could not conclusively prove that semaglutide directly causes NAION, and noted that other factors (such as underlying cardiovascular conditions common in diabetic patients) may play a role
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