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Clinical toxicology (Philadelphia, Pa.), 43(1), 2330

From glucose lowering agents to disease/diabetes modifying drugs: a SIMPLE approach for the treatment of type 2 diabetes

The synergy between the two receptor pathways is present even at low doses, which is an argument for tirzepatide-based microdosing over semaglutide-based microdosing from a metabolic standpoint

Their differing mechanistic profiles make them valuable tools for comparative studies of peptide-mediated signaling and cellular regulatory processes.