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Topiramate has similar benefits for weight reduction in psychiatric patients, but cognitive impairment limits its usage (McIntyre RS et al, Am J Psychiatry 2024;181(1):2638)
In the STEP-1 extension the regain accumulated steadily across the year off the drug rather than appearing all at once, and SURMOUNT-4 showed a similar progressive rise after tirzepatide withdrawal
Once youve lost the weight, you may find yourself off the app, and back to old habits
Semaglutide GLP-1 injections have also been shown to lower the risk of a stroke, heart attack, heart or blood vessel disease, or death in patients that are obese or more at risk for these conditions, and those with type 2 diabetes
At the ultrastructural level, GLP-1R immunoreactivity was observed intracellularly in a few fine processes that were reminiscent of glial processes (Supplementary Fig
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