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However, with a head start following the Wegovy pills approval in December, Novo has seen rapid adoption of its pill, which may dent the uptake of Lillys drug

Conclusion GI AEs are the most common effects of GLP-1 RAs and dual GIP/GLP-1 RAs, often manifesting during initiation and dose escalation

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Taken together, barrier failure, LPS leakage, and TMAO, alongside the hormonal and lipid changes of obesity, form a self-reinforcing axis that connects the intestine to systemic cardiometabolic stress 6

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