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Similarly, ONCOS-102, an engineered adenovirus expressing GM-CSF, has been tested with pembrolizumab in advanced melanoma (NCT03003676), aiming to activate dendritic cells and potentiate T-cellmediated responses

Role of nitric oxide in endotoxic shock

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The deeper layers of the luminal microbiota consume free oxygen to maintain an anaerobic environment that is mainly composed of facultative anaerobes ( Bacteroides and Streptococcus )

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