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Authors contributions AR, FK, EZ, HS, and SM contributed to the conception and design, as well as the acquisition, analysis, and interpretation of data
In vivo experiments confirmed that the MPO/HOCl signaling pathway was significantly activated in the plasma and neurons of SOD1 G93A transgenic mice, which upregulated Caspase-3 expression, downregulated GPX4 and NQO1 expression, significantly elevated plasma MDA levels, promoted neuronal apoptosis, ferroptosis, and lipid peroxidation, and reduced motor performance in mice (Peng et al., 2022)
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L., Stephenson, K
(now part of Viatris) Eli Lilly and Co
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