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DIO mice, JAX cat no
10.1146/annurev-genet-102808-114910 51 HodgkinsonK.El AbbarF.DobranowskiP.ManoogianJ.ButcherJ.FigeysD.et al (2023)
Cycling Protocols: Duration, Rest Periods, and Stacking Cycling refers to the practice of using a compound for a defined period, pausing for a rest period, then resuming if needed
This natural process leads to the production of reactive oxygen species, which are a type of free radical
The senolytic demonstrates preferential elimination of transforming growth factor- (TGF-)-induced myofibroblasts while sparing normal fibroblasts, showing selectivity for pathological senescent cells driving fibrosis
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