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318 : 639 Farlow MR, Lahiri DK, Poirier J, Davignon J, Schneider L, Hui SL
The difference is potency: degraded tesamorelin produces a smaller GH pulse and lower IGF-1 elevation, but the peptide fragments still clear within the same 23 hour window
Participants began with a starting dose of 0.25 mg per week for both cagrilintide and semaglutide, with the doses co-escalated every four weeks (to 0.5 mg, 1.0 mg, and 1.7 mg) until reaching the maintenance dose of 2.4 mg per week for each medication after 16 weeks
However, the human genome may not have adapted to this "recent switch" to higher IIS driven by Western diet
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