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The liposomes loaded with Pde3b siRNA polarized macrophage to M2 by enhancing PKA-CREB-C/EBP pathway, reduced inflammatory response, suppressed synoviocyte infiltration, and alleviated bone and cartilage erosion (131)
Kanel SR, et al
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The overall heterogeneity for HHF was I 2 = 0% (95% uncertainty intervals, 0 and 48.0%) (null) (Additional file 1: Table S3), with no evidence of publication bias (Egger test, P = 0.413)
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