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Moreover, none of the included studies conducted systematic analyses of small moleculeprotein interactions, and the pharmacokinetic relevance of the doses used in vitro versus in vivo studies remains largely unaddressed
The lanes labeled 1, 2, and 3 correspond to LMNG/CHS solubilized fraction, anti-FLAG column flow-through, and purified complex, respectively for both ( c ) and ( d )
Nevertheless, these effects are often markedly attenuated following oral administration due to their poor stability and limited bioavailability under physiological conditions
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