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Description

In the simplest version, transwell models represent endothelial cells cultured on a matrix-coated permeable membrane inserts for the standard cell culture plates, which divide the cultivation well into two parts, imitating the blood-facing and brain-facing compartments of the barrier

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Heavier individuals also tend to tolerate escalation steps more smoothly because the per-kilogram exposure at each dose level is lower

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Underlying infection must be ruled out in all cases with GI problems [7,52-56]

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