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10.1073/pnas.96.24.14165 86 MittlerR.VanderauweraS.GolleryM.Van BreusegemF
Lowering GSH levels also triggers ferroptosis through deactivation of GPX4, leading to accumulation of lipid peroxides [87] In some cases, GSH depletion alone can induce therapeutic effects without relying on Fenton chemistry, which typically involves HO reacting with Fe 2 to form hydroxyl radicals (OH) that damage critical biomolecules such as DNA, proteins, and lipids
To continue making progress, apply the principle of progressive overload
Mean reductions from baseline in A1C were generally greater for patients with higher baseline A1C values
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