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Although ischemic optic neuropathy was rare, it is clinically important because it can involve sudden vision loss, said Chintan Dave, a core faculty member of the Center for Pharmacoepidemiology and Treatment Science at Rutgers Institute for Health, Health Care Policy and Aging Research

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61,103 However, at higher concentrations, uric acid reduces NO bioavailability, impairs eNOS function, reduces NO production, and further exacerbates endothelial cell dysfunction