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The incidence rates compare favorably to placebo groups in controlled trials, indicating that some reported effects may not be causally related to the peptide

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They contribute to the development and expansion of tumor blood vessels by secreting angiogenic factors like Vascular Endothelial Growth Factor (VEGF) and engaging in interactions with macrophages and tumor cells, ultimately influencing the migration and invasion of tumor cells ( The synthetic NBD peptide, which mimics the S100A4-binding domain of MetAP2, has been demonstrated to regulate the expression of genes related to angiogenesis and suppress capillary formation in murine endothelial cells (Takenaga et al., 2021)